Conducting a Phase Zero Study to Examine Hematologic Toxicities & Understand Dose-Limiting Effects & Mechanistic Uncertainty caused by Bystander Irradiation
- Characterizing early hematologic effects and dose-limiting toxicities using Phase 0 microdosing studies
- Dissecting mechanisms of bystander irradiation contributing to bone marrow exposure and cytopenias
- Informing dose escalation and safety margins for subsequent first-in-human and Phase 1 trials