Integrating Imaging‑Derived Dosimetry & Target Confirmation to Optimize Therapeutic First‑in‑Human Study Design
- Translating diagnostic imaging biodistribution into therapeutic dose estimates and dosimetry thresholds for cycle scheduling
- Defining target expression and on-target binding criteria via pre-treatment scans to guide patient selection and reduce off-target risk
- Planning treatment cycles and follow-up intervals based on calculated organ dose limits, expected adverse-event kinetics, and recovery profiles