Overcoming Tumor Retention Challenges in Radioligand Therapy Through Proximity-Induced Covalent Binding
- Increasing tumor uptake and retention of radioligands by forming irreversible covalent linkages with the target
- Maintaining favorable pharmacokinetics and minimizing normal tissue exposure to improve safety
- Improving therapeutic efficacy of alpha- and beta-emitter TRTs, extending tumor residence time and inhibiting growth more effectively than conventional noncovalent approaches