Redefining Dose Optimization for RLT by Moving Beyond Maximum Tolerated Dose to Maximize Efficacy, Safety & Patient Benefit
- Challenging traditional 3+3 dose escalation procedures for RLT dosing, given their limited efficiency and ability to capture cumulative radiation effects
- Comparing dose escalation versus dose accumulation strategies in radiopharmaceutical therapy, with emphasis on safety, exposure, and dose-response characterization
- Incorporating dosimetry-informed or model-based designs into early RLT trials to better link delivered radiation dose with safety and efficacy outcomes