Transforming Outcomes in Advanced SSTR-Positive Neuroendocrine Tumors: Phase 3 Progress with ^225Ac-DOTATATE Targeted Alpha Therapy

  • Improving antitumor efficacy in β-PRRT–refractory NETs through high-LET-particle cytotoxicity
  • Addressing dosimetry, radionuclide supply, and daughter isotope redistribution to optimize safety
  • Expanding clinical accessibility via novel chelators, combination strategies, and optimized radiolabeling protocols