Dose Optimization in Radiotherapeutics: Lessons from Approved Clinical Pharmacology Reviews
- Leverage clinical pharmacology benchmarks from approved radiotherapeutics to investigate dose-optimization strategies utilizing a totality of evidence (dosimetry/PK, efficacy, and safety).
- Synthesize contemporary study designs and methodologies for characterizing key intrinsic and extrinsic patient factors, including body weight, renal/hepatic impairment, QTc prolongation, and drug interactions.
- Evaluate the clinical impact of these patient-specific variables on biodistribution/dosimetry, therapeutic efficacy, and safety profiles.