Michael Evans
Professor University of California, San Francisco
Seminars
Thursday 23rd July 2026
Overcoming Tumor Retention Challenges in Radioligand Therapy Through Proximity-Induced Covalent Binding
2:30 pm
- Increasing tumor uptake and retention of radioligands by forming irreversible covalent linkages with the target
- Maintaining favorable pharmacokinetics and minimizing normal tissue exposure to improve safety
- Improving therapeutic efficacy of alpha- and beta-emitter TRTs, extending tumor residence time and inhibiting growth more effectively than conventional noncovalent approaches
