8:00 am
Registration & Morning Coffee

8:50 am Chair’s Opening Remarks

Designing Logical Combination Therapies

9:00 am Developments in Treating Prostate Cancer with RLT

  • Oliver Sartor Laborde Professor for Cancer Research, Medical Director Tulane Cancer Center, Associate Dean for Oncology , Tulane Medical School

Synopsis

  • Integrating PSMA Radiotherapeutics into clinical practice
  • Thoughts on how RLT could develop into a second/first-line therapy in coming
    years

9:30 am Building Theranostic & Diagnostic Pairings

Synopsis

  • Pros and cons of pairings
  • The right emitter for the right indication
  • The greater vision

10:00 am Logical Combination Therapies for Targeted Alpha Therapies

  • Volker Wagner Head of Clinical Development Radiopharmaceutical , Bayer

Synopsis

  • Targeted alpha therapies induce (clustered) DNA double-strand breaks leading to cell death
  • Combination with inhibitors of DNA damage response may increase efficacyPotential for immune system activation

10:30 am Pb-203/Pb-212: an Emerging Theranostic Isotopologue

  • Amos Hedt Chief Business Strategy Officer , Viewpoint Molecular Targeting, Inc

Synopsis

  • Theranostic pairs: what implications are there for matched and non-matched elements? Chemical, biological, developmental, logistical, commercial and regulatory aspects
  • Pb-203/Pb-212 history, current state of development, and future potential.
  • Next steps for radiopharmaceuticals: the curative potential of combination therapies. Targeted alpha particle therapy is showing great promise in combination with immunotherapy.

11:00 am
Morning Networking & Refreshment Break

11:30 am Locating Sites that Meet the Requirements of Radioligand Developers

Synopsis

  • What can be done to create more spaces for RLT developers to conduct trials?
  • It currently takes 600 hours to train in administering RLT therapies: How can this be best addressed to spread RLT further
  • Meeting the requirements for both adult patients and paediatrics

Leveraging Clinical Trial Logistics & Resources

12:00 pm Scaling Up Efficiently to Meet Commercial Goals

Synopsis

  • Discuss planning, and roll out of program to scale up RLT manufacturing facilities
  • Consider potential bottlenecks and potential challenges of a collaborative vs. solo approach

12:30 pm Clinical Trials with Radiopharmaceuticals: Who is in charge?

Synopsis

  • Oncology or Nuclear Medicine? Who decides?
  • Clinical trial design for radiopharmaceuticals: Oncology or NM perspective?
  • Clinical trial design for radiopharmaceuticals: Words matter!

Harnessing Dosimetry Studies to Improve Gain Clarity on Absorption

1:00 pm
Lunch Break

2:00 pm The Radiochemistry, Preclinical Efficacy & Immunogenicity Of 212Pb- Based Radiopharmaceuticals

  • Mengshi Li Principal Scientist , Viewpoint Molecular Targeting, Inc.

Synopsis

  • Develop radiochemistry for rapid reaction with Pb-212 and stable chelation of progeny Bi-212 daughters
  • Pb-203 surrogate predicts in vivo biodistribution of Pb-212 and progeny Bi-212
  • The immunogenicity of alpha-radiotherapy and synergy with immunotherapy in
    melanoma

2:30 pm Panel Discussion: Striking a Balance: Achieving Anticancer Activity without Toxicity

  • Kelly Orcutt Senior Principal Scientist , Viewpoint Molecular Targeting Inc
  • Manuel Bardiès Cancer Research Institute , Montpellier, France
  • Mengshi Li Principal Scientist , Viewpoint Molecular Targeting, Inc.

Synopsis

  • Consider how we can investigate toxicity through dosimetry and how this data can be used in regulator submissions
  • Discuss how dosimetry will play a role in taking on new cancer types
  • How can we overcome the lack of clarity around the application and value of
    dosimetry?

3:15 pm
Afternoon Refreshment & Networking Break

Securing Funding to Protect & Drive Future Research

3:45 pm Panel Discussion: Riding the Wave: Capitalizing on the Recent Influx of Investment in Radiopharmaceuticals

  • Kemp Dolliver Senior Analyst/ Director of Research , Brookline Capital Markets
  • Ken Song Chairman of the Board & Founder , Rayze Bio

Synopsis

  • Discuss how recent investment has changed the radiopharmaceutical ecosystem
  • Highlight key trends and consider where future funding will be best placed to ‘raise the tide’ for the entire field

4:15 pm The Obstacles to Radiopharmaceutical Innovation & How to Overcome Them

  • Kemp Dolliver Senior Analyst/ Director of Research , Brookline Capital Markets

Synopsis

  • Quantifying theranostics potential
  • In the context of the recent influx of investment in the North America, where should you go looking during your next funding series
  • Incentive borderlines: How to collaborate with academic
  • Isotopes in medicine: A dilemma or a game-changer

4:45 pm Chair’s Closing Remarks